Expression of Soluble Adenylyl Cyclase in Lentigo Maligna: Use of Immunohistochemistry With Anti–Soluble Adenylyl Cyclase Antibody (R21) in Diagnosis of Lentigo Maligna and Assessment of Margins
نویسندگان
چکیده
منابع مشابه
Lentigo maligna and lentigo maligna melanoma.
Lentigo maligna (LM) is a pigmented lesion that occurs on the sun-exposed skin, particularly the head and neck areas, of an older patient. The lesion increases in size and at some point, often many years after its onset, may become lentigo maligna melanoma (LMM). For this reason, most authors consider LM a form of melanoma in situ. Treatment includes surgical or destructive modalities; the pref...
متن کاملTreatment of lentigo maligna and lentigo maligna melanoma.
Thirty-eight cases of lentigo maligna and 22 cases of lentigo maligna melanoma, were reviewed in order to compare cure rates of various methods of treatment. Surgical excision resulted in the best cure rate (91%); destructive modalities were less successful (45%). All lesions treated with 5% 5-fluorouracil recurred.
متن کاملSurgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision.
OBJECTIVES To assess the margins required for excision of lentigo maligna (LM) and lentigo maligna melanoma (LMM) by the technique of mapped serial excision (MSE), and to assess the efficacy of MSE. DESIGN An interventional, prospective, noncontrolled case series. SETTING Tertiary referral, dermatologic surgery unit. PATIENTS Consecutive patients with head and neck LM or LMM who underwent...
متن کاملReviewing Challenges in the Diagnosis and Treatment of Lentigo Maligna and Lentigo-Maligna Melanoma
Lentigo maligna (LM) and lentigo-maligna melanoma (LMM) are pigmented skin lesions that may exist on a continuous clinical and pathological spectrum of melanocytic skin cancer. LM is often described as a "benign" lesion and is accepted as a melanoma in situ; LM can undergo malignant transformation to particularly aggressive melanoma. LMM is an invasive melanoma that shares properties of LM, as ...
متن کاملLentigo maligna and lentigo maligna melanoma: contemporary issues in diagnosis and management
Dermatology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA *Author for correspondence: [email protected] SUMMARY Lentigo maligna and lentigo maligna melanomas present diagnostic and treatment dilemmas due to their frequent presence within a background of sun-damaged skin, and their location o...
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ژورنال
عنوان ژورنال: Archives of Pathology & Laboratory Medicine
سال: 2012
ISSN: 1543-2165,0003-9985
DOI: 10.5858/arpa.2011-0617-oa